MolNFT v1 · #14529 · protein

Solution structure of MDVL1 PDZ domain

1MC7 · Segment polarity protein dishevelled homolog dvl-1: “Solution structure of MDVL1 PDZ domain”. Solution nmr, 1 pocket (best druggability 0.73). MolNFT v1 #14529 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1MC7
Type: protein
Length: 95 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Segment polarity protein dishevelled homolog dvl-1
UniProt: P51141
Pockets: 1 · best druggability 0.73

Structure

solution nmr · 1 distinct chain · 17% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Segment polarity protein dishevelled homolog dvl-1	protein	95	17% helix, 17% strand	P51141

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.73	0.91	32	empty

Compared structures

1MC7 · Solution Structure of mDvl1 PDZ domain · the same entry in another collection · chain A against A, TM-score 1.00
P51141 · AlphaFold monomer V2.0 prediction for segment polarity protein dishevelled homolog dvl-1… · a predicted model of the same protein · chain A against A, TM-score 0.66

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51141
Elsewhere: RCSB PDB 1MC7 · PDBe 1MC7 · UniProt P51141

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