MolNFT v1 · #145218 · protein

Crystal structure of laci family transcriptional regulator from lactobacillus casei, target efi-512911, with bound tris

6CHK · Transcriptional regulator, laci family: “Crystal structure of laci family transcriptional regulator from lactobacillus casei, target efi-512911, with…”. X-ray diffraction, 2 ligands (NA, CL), 1 pocket (best druggability 0.74).…

PDB: 6CHK
Type: protein
Length: 270 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulator, laci family
UniProt: Q036L9
Ligands: NA, CL
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional regulator, laci family	protein	270	41% helix, 16% strand	Q036L9

Ligands and binding sites

NA · Sodium ion · metal · chains A
CL · Chloride ion · ion · chains A
TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	466	0.74	0.83	38	TRS

Compared structures

6CHK · Crystal structure of LacI family transcriptional regulator from Lactobacillus casei… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q036L9
Elsewhere: RCSB PDB 6CHK · PDBe 6CHK · UniProt Q036L9

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