MolNFT v1 · #14521 · protein

Murine sak polo domain

1MBY · SERINE/THREONINE kinase: “Murine sak polo domain”. X-ray diffraction, 1 pocket (best druggability 0.80). MolNFT v1 #14521 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1MBY
Type: protein
Length: 150 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE kinase
EC: 2.7.1.37
UniProt: Q64702
Pockets: 1 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 9% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	SERINE/THREONINE kinase (EC 2.7.1.37)	protein	75	9% helix, 53% strand	Q64702

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	510	0.80	0.86	50	empty

Interfaces

1 interface between chains.

A–B · 1256 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

1MBY · Murine Sak Polo Domain · the same entry in another collection · chain A against A, TM-score 1.00
Q64702 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (Q64702) · a predicted model of the same protein · chain A against A, TM-score 0.52

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q64702
Elsewhere: RCSB PDB 1MBY · PDBe 1MBY · UniProt Q64702

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