MolNFT v1 · #145162 · protein
Structure of the DASH/DAM1 complex shows its role at the yeast kinetochore-microtubule interface
6CFZ · ASK1: “Structure of the DASH/DAM1 complex shows its role at the yeast kinetochore-microtubule interface”. Electron microscopy, 13 pockets (best druggability 0.88). MolNFT v1 #145162 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6CFZ
- Type
- protein
- Length
- 761 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ASK1; DAD3; DAD2; DUO1; DAD4; DAD1,DAD1; HSK3; DAM1; SPC19; SPC34
- UniProt
- G0S8F9, G0RY74, G0RZB3, G0SAN7, G0S589, G0RYE9, G0S2K4, G0S0N0, G0S2A3
- Pockets
- 13 · best druggability 0.88
Structure
electron microscopy · 10 distinct chains · 85% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ASK1 | protein | 66 | 95% helix, 0% strand | G0S8F9 |
| B | DAD3 | protein | 65 | 97% helix, 0% strand | G0RY74 |
| C | DAD2 | protein | 79 | 84% helix, 0% strand | G0RZB3 |
| D | DUO1 | protein | 73 | 89% helix, 0% strand | G0SAN7 |
| E | DAD4 | protein | 68 | 87% helix, 0% strand | G0S589 |
| F | DAD1,DAD1 | protein | 59 | 88% helix, 0% strand | G0RYE9 |
| G | HSK3 | protein | 56 | 96% helix, 0% strand | — |
| H | DAM1 | protein | 55 | 87% helix, 0% strand | G0S2K4 |
| I | SPC19 | protein | 106 | 83% helix, 0% strand | G0S0N0 |
| J | SPC34 | protein | 134 | 66% helix, 0% strand | G0S2A3 |
Pockets
13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 718 | 0.88 | 0.91 | 89 | empty |
| 2 | 493 | 0.85 | 0.91 | 75 | empty |
| 3 | 288 | 0.80 | 0.91 | 42 | empty |
| 4 | 143 | 0.64 | 0.86 | 26 | empty |
| 5 | 134 | 0.61 | 0.85 | 32 | empty |
Interfaces
29 interfaces between chains.
- I–J · 1654 Ų buried · 11 hydrogen bonds · protein-protein
- C–I · 1449 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 1284 Ų buried · 1 hydrogen bond · protein-protein
- A–E · 1162 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 1048 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6CFZ · Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S8F9
- Every structure of UniProt G0RY74
- Every structure of UniProt G0RZB3
- Every structure of UniProt G0SAN7
- Every structure of UniProt G0S589
- Every structure of UniProt G0RYE9
- Every structure of UniProt G0S2K4
- Every structure of UniProt G0S0N0
- Every structure of UniProt G0S2A3
- Elsewhere: RCSB PDB 6CFZ · PDBe 6CFZ · UniProt G0S8F9 · UniProt G0RY74 · UniProt G0RZB3 · UniProt G0SAN7 · UniProt G0S589 · UniProt G0RYE9 · UniProt G0S2K4 · UniProt G0S0N0 · UniProt G0S2A3
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