MolNFT v1 · #145032 · protein

Crystal structure of CDC45 from entamoeba histolytica

6CC2 · Cell division control protein 45 CDC45 putative: “Crystal structure of CDC45 from entamoeba histolytica”. X-ray diffraction, 1 ligand (CL), 4 pockets (best druggability 0.86). MolNFT v1 #145032 on GenesisL1: 3D structure, binding…

PDB: 6CC2
Type: protein
Length: 502 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division control protein 45 CDC45 putative
UniProt: A0A175JFA5
Ligands: CL
Pockets: 4 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cell division control protein 45 CDC45 putative	protein	502	51% helix, 18% strand	A0A175JFA5

Ligands and binding sites

CL · Chloride ion · ion · 3 copies · chains A
EDO · 1,2-ethanediol · additive · 12 copies · chains A
PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1086	0.86	0.87	103	CL
2	186	0.64	0.84	23	EDO
3	88	0.33	0.73	17	empty
4	52	0.28	0.75	15	empty

Modifications

Observed in the structure: 14 modified (engineered, artifact).

Compared structures

6CC2 · Crystal Structure of CDC45 from Entamoeba histolytica · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A175JFA5
Elsewhere: RCSB PDB 6CC2 · PDBe 6CC2 · UniProt A0A175JFA5

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