MolNFT v1 · #144975 · protein
Crystal structure of plasmodium falciparum topoisomerase II DNA- binding, cleavage and re-ligation domain
6CA8 · DNA topoisomerase 2: “Crystal structure of plasmodium falciparum topoisomerase II DNA- binding, cleavage and re-ligation domain”. X-ray diffraction, 7 pockets (best druggability 0.78). MolNFT v1 #144975 on GenesisL1: 3D structure…
- PDB
- 6CA8
- Type
- protein
- Length
- 731 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA topoisomerase 2
- EC
- 5.99.1.3
- UniProt
- Q7Z2D0
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 2 (EC 5.99.1.3) | protein | 731 | 46% helix, 15% strand | Q7Z2D0 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1114 | 0.78 | 0.80 | 77 | empty |
| 2 | 410 | 0.67 | 0.80 | 41 | empty |
| 3 | 317 | 0.62 | 0.79 | 42 | empty |
| 4 | 106 | 0.38 | 0.74 | 14 | empty |
| 5 | 62 | 0.33 | 0.76 | 16 | empty |
Compared structures
- 6CA8 · Crystal structure of Plasmodium falciparum topoisomerase II DNA-binding, cleavage and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z2D0
- Elsewhere: RCSB PDB 6CA8 · PDBe 6CA8 · UniProt Q7Z2D0
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