MolNFT v1 · #144865 · protein

Cryo-EM structure of orco

6C70 · Odorant receptor: “Cryo-EM structure of orco”. Electron microscopy, 20 pockets (best druggability 0.77). MolNFT v1 #144865 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6C70
Type: protein
Length: 1,552 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Odorant receptor
UniProt: B0FAQ4
Pockets: 20 · best druggability 0.77

Structure

electron microscopy · 1 distinct chain · 74% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Odorant receptor	protein	388	74% helix, 1% strand	B0FAQ4

Pockets

20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1097	0.77	0.78	86	empty
2	508	0.74	0.82	53	empty
3	610	0.73	0.80	67	empty
4	510	0.72	0.81	56	empty
5	306	0.70	0.84	28	empty

Interfaces

6 interfaces between chains.

A–D · 1324 Å² buried · 9 hydrogen bonds · protein-protein
C–D · 1322 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 1303 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 1296 Å² buried · 9 hydrogen bonds · protein-protein
B–D · 74 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6C70 · Cryo-EM structure of Orco · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B0FAQ4
Elsewhere: RCSB PDB 6C70 · PDBe 6C70 · UniProt B0FAQ4

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