MolNFT v1 · #144831 · protein
MHC-independent T-cell receptor B12A
6C61 · T-cell receptor alpha chain: “MHC-independent T-cell receptor B12A”. X-ray diffraction, 2 pockets (best druggability 0.71). MolNFT v1 #144831 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6C61
- Type
- protein
- Length
- 449 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-cell receptor alpha chain; T-cell receptor beta chain
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | T-cell receptor alpha chain | protein | 206 | 3% helix, 47% strand | — |
| B | T-cell receptor beta chain | protein | 243 | 7% helix, 50% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1080 | 0.71 | 0.75 | 81 | empty |
| 2 | 56 | 0.29 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2259 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6C61 · MHC-independent T-cell receptor B12A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6C61 · PDBe 6C61
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