MolNFT v1 · #14480 · protein

Crystal structure to 2.45 a resolution of a monoclonal Fab specific for the brucella a cell wall polysaccharide antigen

1MAM · IGG2B-kappa YST9.1 Fab (light chain): “Crystal structure to 2.45 a resolution of a monoclonal Fab specific for the brucella a cell wall…”. X-ray diffraction, 3 pockets (best druggability 0.44). MolNFT v1 #14480 on GenesisL1: 3D…

PDB: 1MAM
Type: protein
Length: 431 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: IGG2B-kappa YST9.1 Fab (light chain); IGG2B-kappa YST9.1 Fab (heavy chain)
UniProt: P01867
Pockets: 3 · best druggability 0.44

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	IGG2B-kappa YST9.1 Fab (light chain)	protein	214	7% helix, 50% strand	—
H	IGG2B-kappa YST9.1 Fab (heavy chain)	protein	217	3% helix, 49% strand	P01867

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	140	0.44	0.76	24	empty
2	166	0.41	0.73	22	empty
3	92	0.37	0.75	21	empty

Interfaces

1 interface between chains.

L–H · 1751 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1MAM · Crystal structure to 2.45 a resolution of a monoclonal Fab specific for the brucella a… · the same entry in another collection · chain L against L, TM-score 1.00
P01867 · AlphaFold monomer V2.0 prediction for ig gamma-2B chain C region (P01867) · a predicted model of the same protein · chain H against A, TM-score 0.50

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01867
Elsewhere: RCSB PDB 1MAM · PDBe 1MAM · UniProt P01867

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