MolNFT v1 · #144642 · protein
Structure of the hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 19B3
6BZU · 19B3 heavy chain: “Structure of the hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly…”. X-ray diffraction, 19 pockets (best druggability 0.68). MolNFT v1 #144642 on GenesisL1: 3D structure…
- PDB
- 6BZU
- Type
- protein
- Length
- 1,748 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 19B3 heavy chain; 19B3 light chain; E2 AS412 peptide
- Pockets
- 19 · best druggability 0.68
Structure
x-ray diffraction · 12 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 19B3 heavy chain | protein | 217 | 7% helix, 52% strand | — |
| B | 19B3 light chain | protein | 216 | 6% helix, 51% strand | — |
| C | 19B3 heavy chain | protein | 218 | 8% helix, 53% strand | — |
| D | 19B3 light chain | protein | 214 | 6% helix, 52% strand | — |
| E | 19B3 heavy chain | protein | 192 | 6% helix, 52% strand | — |
| F | 19B3 light chain | protein | 214 | 6% helix, 50% strand | — |
| G | 19B3 heavy chain | protein | 220 | 5% helix, 51% strand | — |
| H | 19B3 light chain | protein | 215 | 6% helix, 53% strand | — |
| I | E2 AS412 peptide | protein | 9 | 0% helix, 44% strand | — |
| J | E2 AS412 peptide | protein | 10 | 0% helix, 40% strand | — |
| K | E2 AS412 peptide | protein | 11 | 0% helix, 55% strand | — |
| L | E2 AS412 peptide | protein | 12 | 0% helix, 67% strand | — |
Pockets
19 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 781 | 0.68 | 0.76 | 69 | empty |
| 2 | 788 | 0.68 | 0.75 | 64 | empty |
| 3 | 685 | 0.65 | 0.75 | 69 | empty |
| 4 | 653 | 0.64 | 0.74 | 60 | empty |
| 5 | 283 | 0.54 | 0.76 | 31 | empty |
Interfaces
15 interfaces between chains.
- C–D · 2011 Ų buried · 12 hydrogen bonds · protein-protein
- G–H · 1997 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1992 Ų buried · 15 hydrogen bonds · protein-protein
- E–F · 1664 Ų buried · 11 hydrogen bonds · protein-protein
- B–F · 902 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 6BZU · Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6BZU · PDBe 6BZU
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