MolNFT v1 · #144616 · protein + DNA
MEF2 chimera D83V MUTANT/DNA complex
6BZ1: “MEF2 chimera D83V MUTANT/DNA complex”. X-ray diffraction, 4 pockets (best druggability 0.72). MolNFT v1 #144616 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6BZ1
- Type
- protein + DNA
- Length
- 408 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MEF2 chimera; DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'); DNA…
- UniProt
- Q02078, Q02080
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 6 distinct chains · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | MEF2 chimera | protein | 90 | 40% helix, 18% strand | Q02078, Q02080 |
| D | MEF2 chimera | protein | 87 | 41% helix, 18% strand | Q02078, Q02080 |
| G | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3') | dna | 14 | — | — |
| H, F | DNA (5'-D(P*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)- 3') | dna | 13 | — | — |
| A, B | MEF2 chimera | protein | 89 | 40% helix, 17% strand | Q02078, Q02080 |
| E | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3') | dna | 13 | — | — |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 615 | 0.72 | 0.80 | 50 | empty |
| 2 | 312 | 0.58 | 0.77 | 33 | empty |
| 3 | 56 | 0.50 | 0.87 | 18 | empty |
| 4 | 94 | 0.34 | 0.74 | 13 | empty |
Interfaces
20 interfaces between chains.
- C–D · 2810 Ų buried · 45 hydrogen bonds · protein-protein
- A–B · 2719 Ų buried · 41 hydrogen bonds · protein-protein
- G–H · 577 Ų buried · 47 hydrogen bonds · nucleic-nucleic
- E–F · 574 Ų buried · 58 hydrogen bonds · nucleic-nucleic
- C–G · 534 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 6BZ1 · MEF2 Chimera D83V mutant/DNA complex · the same entry in another collection · chain F against F, TM-score 1.00
- Q02080 · AlphaFold monomer V2.0 prediction for myocyte-specific enhancer factor 2B (Q02080) · a predicted model of the same protein · chain D against A, TM-score 0.88
- Q02078 · AlphaFold monomer V2.0 prediction for myocyte-specific enhancer factor 2A (Q02078) · a predicted model of the same protein · chain D against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02078
- Every structure of UniProt Q02080
- Elsewhere: RCSB PDB 6BZ1 · PDBe 6BZ1 · UniProt Q02078 · UniProt Q02080
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