MolNFT v1 · #144575 · protein
Crystal structure of toxoplasma gondii mitochondrial association factor 1 a (MAF1A) in complex with adpribose
6BXT: “Crystal structure of toxoplasma gondii mitochondrial association factor 1 a (MAF1A) in complex with adpribose”. X-ray diffraction, 1 ligand (APR), 6 pockets (best druggability 0.68). MolNFT v1 #144575 on GenesisL1: 3D structure…
- PDB
- 6BXT
- Type
- protein
- Length
- 777 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial association factor 1
- UniProt
- A0A193AUK9
- Ligands
- APR
- Pockets
- 6 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial association factor 1 | protein | 265 | 42% helix, 18% strand | A0A193AUK9 |
| B | Mitochondrial association factor 1 | protein | 259 | 41% helix, 18% strand | A0A193AUK9 |
| C | Mitochondrial association factor 1 | protein | 253 | 43% helix, 18% strand | A0A193AUK9 |
Ligands and binding sites
- APR · Adenosine-5-diphosphoribose · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 361 | 0.68 | 0.81 | 47 | APR |
| 2 | 306 | 0.62 | 0.79 | 40 | APR |
| 3 | 213 | 0.58 | 0.80 | 32 | empty |
| 4 | 244 | 0.58 | 0.79 | 29 | empty |
| 5 | 175 | 0.52 | 0.79 | 24 | empty |
Interfaces
2 interfaces between chains.
- A–B · 581 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 379 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6BXT · Crystal structure of Toxoplasma gondii Mitochondrial Association Factor 1 A (MAF1A) in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A193AUK9
- Elsewhere: RCSB PDB 6BXT · PDBe 6BXT · UniProt A0A193AUK9
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