MolNFT v1 · #14454 · protein

Crystal structure of earthworm fibrinolytic enzyme component a from eisenia fetida

1M9U: “Crystal structure of earthworm fibrinolytic enzyme component a from eisenia fetida”. X-ray diffraction, 4 pockets (best druggability 0.61). MolNFT v1 #14454 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1M9U
Type: protein
Length: 723 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Earthworm fibrinolytic enzyme
EC: 3.4.21.-
UniProt: Q8MX72
Pockets: 4 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Earthworm fibrinolytic enzyme (EC 3.4.21.-)	protein	241	10% helix, 35% strand	Q8MX72

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	444	0.61	0.76	45	empty
2	144	0.48	0.78	25	empty
3	75	0.32	0.74	16	empty
4	62	0.31	0.75	19	empty

Interfaces

3 interfaces between chains.

A–B · 629 Å² buried · 9 hydrogen bonds · protein-protein
B–C · 304 Å² buried · 1 hydrogen bond · protein-protein
A–C · 78 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

1M9U · Crystal Structure of Earthworm Fibrinolytic Enzyme Component A from Eisenia fetida · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8MX72
Elsewhere: RCSB PDB 1M9U · PDBe 1M9U · UniProt Q8MX72

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