MolNFT v1 · #144534 · protein

Crystal structure of the human mlkl pseudokinase domain T357E/S358E mutant

6BWK · Mixed lineage kinase domain-like protein: “Crystal structure of the human mlkl pseudokinase domain T357E/S358E mutant”. X-ray diffraction, 3 pockets (best druggability 0.69). MolNFT v1 #144534 on GenesisL1: 3D structure, binding…

PDB: 6BWK
Type: protein
Length: 263 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mixed lineage kinase domain-like protein
UniProt: Q8NB16
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mixed lineage kinase domain-like protein	protein	263	41% helix, 16% strand	Q8NB16

Ligands and binding sites

GOL · Glycerol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	386	0.69	0.81	36	GOL
2	176	0.46	0.75	24	empty
3	66	0.30	0.74	18	empty

Compared structures

6BWK · Crystal structure of the human MLKL pseudokinase domain T357E/S358E mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q8NB16 · AlphaFold monomer V2.0 prediction for mixed lineage kinase domain- like protein (Q8NB16) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NB16
Elsewhere: RCSB PDB 6BWK · PDBe 6BWK · UniProt Q8NB16

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