MolNFT v1 · #144529 · protein
4.1 ångström MG2+-unbound structure of mouse TRPM7
6BWF: “4.1 ångström MG2+-unbound structure of mouse TRPM7”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #144529 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6BWF
- Type
- protein
- Length
- 3,064 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRPM7
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 49% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | TRPM7 | protein | 766 | 49% helix, 1% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 796 | 0.82 | 0.84 | 58 | empty |
| 2 | 352 | 0.81 | 0.89 | 43 | empty |
| 3 | 939 | 0.78 | 0.80 | 100 | empty |
| 4 | 760 | 0.77 | 0.81 | 92 | empty |
| 5 | 1026 | 0.76 | 0.78 | 92 | empty |
Interfaces
6 interfaces between chains.
- C–D · 3013 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 2980 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 2962 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 2910 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 56 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6BWF · 4.1 angstrom Mg2+-unbound structure of mouse TRPM7 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6BWF · PDBe 6BWF
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