MolNFT v1 · #144417 · protein

Crystal structure of xyloglucan xylosyltransferase I

6BSU · Xyloglucan 6-xylosyltransferase 1: “Crystal structure of xyloglucan xylosyltransferase I”. X-ray diffraction, 1 ligand (MN), 7 pockets (best druggability 0.75). MolNFT v1 #144417 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 6BSU
Type: protein
Length: 674 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Xyloglucan 6-xylosyltransferase 1
EC: 2.4.2.39
UniProt: Q9LZJ3
Ligands: MN
Pockets: 7 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Xyloglucan 6-xylosyltransferase 1 (EC 2.4.2.39)	protein	337	40% helix, 17% strand	Q9LZJ3

Ligands and binding sites

MN · Manganese (II) ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	502	0.75	0.83	34	empty
2	744	0.75	0.80	75	empty
3	804	0.73	0.78	74	MN
4	190	0.64	0.84	34	empty
5	213	0.61	0.82	35	empty

Interfaces

1 interface between chains.

A–B · 2977 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6BSU · Crystal structure of xyloglucan xylosyltransferase I · the same entry in another collection · chain A against A, TM-score 1.00
Q9LZJ3 · AlphaFold monomer V2.0 prediction for xyloglucan 6-xylosyltransferase 1 (Q9LZJ3) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9LZJ3
Elsewhere: RCSB PDB 6BSU · PDBe 6BSU · UniProt Q9LZJ3

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