MolNFT v1 · #14431 · protein
1.65 a structure of cleaved viral serpin crma
1M93 · Serine proteinase inhibitor 2: “1.65 a structure of cleaved viral serpin crma”. X-ray diffraction, 1 ligand (PO4), 2 pockets (best druggability 0.45). MolNFT v1 #14431 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1M93
- Type
- protein
- Length
- 322 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serine proteinase inhibitor 2
- UniProt
- P07385
- Ligands
- PO4
- Pockets
- 2 · best druggability 0.45
Structure
x-ray diffraction · 3 distinct chains · 23% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serine proteinase inhibitor 2 | protein | 46 | 67% helix, 7% strand | P07385 |
| B | Serine proteinase inhibitor 2 | protein | 245 | 18% helix, 43% strand | P07385 |
| C | Serine proteinase inhibitor 2 | protein | 31 | 0% helix, 55% strand | P07385 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.45 | 0.76 | 25 | empty |
| 2 | 92 | 0.41 | 0.78 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1800 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 1755 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 588 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 1M93 · 1.65 A Structure of Cleaved Viral Serpin CRMA · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07385
- Elsewhere: RCSB PDB 1M93 · PDBe 1M93 · UniProt P07385
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