MolNFT v1 · #144259 · protein

TRPV2 ion channel in partially closed state

6BO5 · Transient receptor potential cation channel subfamily V…: “TRPV2 ion channel in partially closed state”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #144259 on GenesisL1: 3D structure, binding sites and…

PDB: 6BO5
Type: protein
Length: 2,228 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily V member 2
UniProt: Q9WUD2
Pockets: 20 · best druggability 0.87

Structure

electron microscopy · 1 distinct chain · 52% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D, C	Transient receptor potential cation channel subfamily V member 2	protein	557	52% helix, 2% strand	Q9WUD2

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1038	0.87	0.87	116	empty
2	1063	0.86	0.87	98	empty
3	1097	0.86	0.87	101	empty
4	1090	0.86	0.86	103	empty
5	1131	0.85	0.85	85	empty

Interfaces

4 interfaces between chains.

B–C · 1341 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 1337 Å² buried · 4 hydrogen bonds · protein-protein
D–C · 1333 Å² buried · 4 hydrogen bonds · protein-protein
A–D · 1331 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6BO5 · TRPV2 ion channel in partially closed state · the same entry in another collection · chain A against A, TM-score 1.00
Q9WUD2 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WUD2
Elsewhere: RCSB PDB 6BO5 · PDBe 6BO5 · UniProt Q9WUD2

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