MolNFT v1 · #144057 · protein
Mouse immunoglobulin G 2C Fc fragment with single glcnac
6BHY · Igh protein: “Mouse immunoglobulin G 2C Fc fragment with single glcnac”. X-ray diffraction, 2 ligands (NAG, NA), 3 pockets (best druggability 0.64). MolNFT v1 #144057 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6BHY
- Type
- protein
- Length
- 416 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Igh protein
- UniProt
- Q58E56
- Ligands
- NAG, NA
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Igh protein | protein | 209 | 11% helix, 50% strand | Q58E56 |
| B | Igh protein | protein | 207 | 12% helix, 50% strand | Q58E56 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
- NA · Sodium ion · metal · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 550 | 0.64 | 0.76 | 56 | empty |
| 2 | 281 | 0.52 | 0.75 | 40 | empty |
| 3 | 61 | 0.34 | 0.77 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 403 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 6BHY · Mouse Immunoglobulin G 2c Fc fragment with single GlcNAc · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q58E56
- Elsewhere: RCSB PDB 6BHY · PDBe 6BHY · UniProt Q58E56
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.