MolNFT v1 · #143972 · protein
Vinculin homolog in a sponge (phylum porifera) reveals vertebrate-like cell adhesions involved in early multicellular evolution
6BFI · VIN1: “Vinculin homolog in a sponge (phylum porifera) reveals vertebrate-like cell adhesions involved in early…”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #143972 on GenesisL1: 3D structure, binding sites…
- PDB
- 6BFI
- Type
- protein
- Length
- 1,611 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VIN1
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 80% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | VIN1 | protein | 805 | 80% helix, 1% strand | — |
| B | VIN1 | protein | 806 | 80% helix, 1% strand | — |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 919 | 0.84 | 0.86 | 77 | empty |
| 2 | 713 | 0.82 | 0.86 | 64 | empty |
| 3 | 385 | 0.80 | 0.89 | 46 | empty |
| 4 | 457 | 0.77 | 0.85 | 57 | empty |
| 5 | 123 | 0.62 | 0.87 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1593 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6BFI · Vinculin homolog in a sponge (phylum Porifera) reveals vertebrate-like cell adhesions… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6BFI · PDBe 6BFI
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