MolNFT v1 · #14394 · protein

Solution structure and dynamics of the human-escherichia COLI thioredoxin chimera: insights into thermodynamic stability

1M7T · Chimera of human and E. COLI thioredoxin: “Solution structure and dynamics of the human-escherichia COLI thioredoxin chimera: insights into…”. Solution nmr, 1 pocket (best druggability 0.35). MolNFT v1 #14394 on GenesisL1: 3D…

PDB: 1M7T
Type: protein
Length: 107 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chimera of human and E. COLI thioredoxin
UniProt: P10599, P00274
Pockets: 1 · best druggability 0.35

Structure

solution nmr · 1 distinct chain · 40% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chimera of human and E. COLI thioredoxin	protein	107	40% helix, 24% strand	P10599, P00274

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.35	0.79	13	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1M7T · Solution Structure and Dynamics of the Human-Escherichia coli Thioredoxin Chimera… · the same entry in another collection · chain A against A, TM-score 1.00
P10599 · AlphaFold monomer V2.0 prediction for thioredoxin (P10599) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10599
Every structure of UniProt P00274
Elsewhere: RCSB PDB 1M7T · PDBe 1M7T · UniProt P10599 · UniProt P00274

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