MolNFT v1 · #143928 · protein

Crystal structure of a polysaccharide-binding human Fab (F598)

6BE2 · Fab (F598) heavy chain: “Crystal structure of a polysaccharide-binding human Fab (F598)”. X-ray diffraction, 2 pockets (best druggability 0.57). MolNFT v1 #143928 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6BE2
Type: protein
Length: 430 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab (F598) heavy chain; Fab (F598) light chain
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Fab (F598) heavy chain	protein	217	6% helix, 53% strand	—
L	Fab (F598) light chain	protein	213	8% helix, 54% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	483	0.57	0.73	48	empty
2	58	0.26	0.73	13	empty

Interfaces

1 interface between chains.

H–L · 1584 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6BE2 · Crystal structure of a polysaccharide-binding human Fab (F598) · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6BE2 · PDBe 6BE2

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