MolNFT v1 · #14392 · protein
Crystal structure of myotubularin-related protein-2 (MTMR2) complexed with phosphate
1M7R: “Crystal structure of myotubularin-related protein-2 (MTMR2) complexed with phosphate”. X-ray diffraction, 1 ligand (PO4), 12 pockets (best druggability 0.69). MolNFT v1 #14392 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1M7R
- Type
- protein
- Length
- 1,026 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myotubularin-related protein-2
- EC
- 3.1.3.64
- UniProt
- Q13614
- Ligands
- PO4
- Pockets
- 12 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Myotubularin-related protein-2 (EC 3.1.3.64) | protein | 513 | 39% helix, 17% strand | Q13614 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 248 | 0.69 | 0.84 | 30 | empty |
| 2 | 266 | 0.68 | 0.84 | 27 | empty |
| 3 | 434 | 0.68 | 0.80 | 30 | empty |
| 4 | 50 | 0.61 | 0.93 | 15 | empty |
| 5 | 282 | 0.56 | 0.76 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 864 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 1M7R · Crystal Structure of Myotubularin-related Protein-2 (MTMR2) Complexed with Phosphate · the same entry in another collection · chain A against A, TM-score 1.00
- Q13614 · AlphaFold monomer V2.0 prediction for myotubularin-related protein 2 (Q13614) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13614
- Elsewhere: RCSB PDB 1M7R · PDBe 1M7R · UniProt Q13614
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.