MolNFT v1 · #143730 · protein

Crystal structure of transmembrane protein TMHC2_E

6B87: “Crystal structure of transmembrane protein TMHC2_E”. X-ray diffraction, 5 pockets (best druggability 0.54). MolNFT v1 #143730 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6B87
Type: protein
Length: 398 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TMHC2_E
Pockets: 5 · best druggability 0.54

Structure

x-ray diffraction · 4 distinct chains · 93% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TMHC2_E	protein	100	90% helix, 0% strand	—
B	TMHC2_E	protein	96	95% helix, 0% strand	—
C	TMHC2_E	protein	100	94% helix, 0% strand	—
D	TMHC2_E	protein	102	95% helix, 0% strand	—

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	176	0.54	0.78	22	empty
2	117	0.50	0.80	22	empty
3	99	0.40	0.76	24	empty
4	56	0.31	0.75	12	empty
5	57	0.28	0.73	13	empty

Interfaces

4 interfaces between chains.

C–D · 1935 Å² buried · 6 hydrogen bonds · protein-protein
A–C · 650 Å² buried · 2 hydrogen bonds · protein-protein
B–D · 430 Å² buried · 0 hydrogen bonds · protein-protein
A–D · 175 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6B87 · Crystal structure of transmembrane protein TMHC2_E · the same entry in another collection · chain D against D, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6B87 · PDBe 6B87

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