MolNFT v1 · #143640 · protein

Structure of pfcsp peptide 20 with human protective antibody CIS43

6B5L · CIS43 Fab heavy chain: “Structure of pfcsp peptide 20 with human protective antibody CIS43”. X-ray diffraction, 2 pockets (best druggability 0.65). MolNFT v1 #143640 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6B5L
Type: protein
Length: 448 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CIS43 Fab heavy chain; CIS43 Fab light chain; Pfcsp peptide 20…
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 3 distinct chains · 7% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	CIS43 Fab heavy chain	protein	220	8% helix, 53% strand	—
L	CIS43 Fab light chain	protein	218	6% helix, 53% strand	—
A	Pfcsp peptide 20: asn-pro-asp-pro-asn-ala-asn-pro-asn-val	protein	10	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	651	0.65	0.75	66	empty
2	63	0.30	0.75	15	empty

Interfaces

3 interfaces between chains.

H–L · 1881 Å² buried · 11 hydrogen bonds · protein-protein
H–A · 366 Å² buried · 12 hydrogen bonds · protein-protein
L–A · 338 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6B5L · Structure of PfCSP peptide 20 with human protective antibody CIS43 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6B5L · PDBe 6B5L

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