MolNFT v1 · #143633 · protein

Mycobacterium tuberculosis rmla in complex with dtdp-glucose

6B5E: “Mycobacterium tuberculosis rmla in complex with dtdp-glucose”. X-ray diffraction, 5 ligands (DAU, TYD, MG). MolNFT v1 #143633 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6B5E
Type: protein
Length: 2,274 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P9WH13
Ligands: DAU, TYD, MG, NA, CL

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	283	—	P9WH13
B, C, D, E	—	protein	286	—	P9WH13
F, G	—	protein	284	—	P9WH13
H	—	protein	279	—	P9WH13

Ligands and binding sites

DAU · 2'deoxy-thymidine-5'-diphospho-alpha-D-glucose · ligand · 10 copies · chains A, B, C, D, E, F, G, H
TYD · Thymidine-5'-diphosphate · ligand · 6 copies · chains A, B, C, D, G, H
MG · Magnesium ion · metal · 9 copies · chains A, B, C, D, E, F, G, H
NA · Sodium ion · metal · 2 copies · chains B, C
CL · Chloride ion · ion · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6B5E · Mycobacterium tuberculosis RmlA in complex with dTDP-glucose · the same entry in another collection · chain H against H, TM-score 1.00
P9WH13 · AlphaFold monomer V2.0 prediction for glucose-1-phosphate thymidylyltransferase (P9WH13) · a predicted model of the same protein · chain H against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WH13
Elsewhere: RCSB PDB 6B5E · PDBe 6B5E · UniProt P9WH13

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