MolNFT v1 · #143616 · protein
Schistosoma mansoni (blood fluke) sulfotransferase, F39Y mutant
6B4X · Sulfotransferase oxamniquine resistance protein: “Schistosoma mansoni (blood fluke) sulfotransferase, F39Y mutant”. X-ray diffraction, 2 ligands (A3P, NA), 3 pockets (best druggability 0.78). MolNFT v1 #143616 on GenesisL1: 3D…
- PDB
- 6B4X
- Type
- protein
- Length
- 256 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sulfotransferase oxamniquine resistance protein
- EC
- 2.8.2.-
- UniProt
- G4VLE5
- Ligands
- A3P, NA
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 54% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sulfotransferase oxamniquine resistance protein (EC 2.8.2.-) | protein | 256 | 54% helix, 7% strand | G4VLE5 |
Ligands and binding sites
- A3P · Adenosine-3'-5'-diphosphate · ligand · chains A
- NA · Sodium ion · metal · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 232 | 0.78 | 0.91 | 37 | TRS |
| 2 | 139 | 0.57 | 0.83 | 25 | A3P |
| 3 | 90 | 0.31 | 0.72 | 17 | empty |
Modifications
Observed in the structure: 1 modified (artifact).
Compared structures
- 6B4X · Schistosoma mansoni (Blood Fluke) Sulfotransferase, F39Y Mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G4VLE5
- Elsewhere: RCSB PDB 6B4X · PDBe 6B4X · UniProt G4VLE5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.