MolNFT v1 · #14358 · protein
Extracytoplasmic domain of bovine cation-dependent mannose 6-phosphate receptor
1M6P · Cation-dependent mannose-6-phosphate receptor: “Extracytoplasmic domain of bovine cation-dependent mannose 6-phosphate receptor”. X-ray diffraction, 2 ligands (M6P, MN), 1 pocket (best druggability 0.69). MolNFT v1 #14358 on…
- PDB
- 1M6P
- Type
- protein
- Length
- 292 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cation-dependent mannose-6-phosphate receptor
- UniProt
- P11456
- Ligands
- M6P, MN
- Pockets
- 1 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 12% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cation-dependent mannose-6-phosphate receptor | protein | 146 | 12% helix, 41% strand | P11456 |
Ligands and binding sites
- M6P · 6-O-phosphono-alpha-D-mannopyranose · ligand · 2 copies · chains A, B
- MN · Manganese (II) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 294 | 0.69 | 0.83 | 36 | empty |
Interfaces
1 interface between chains.
- A–B · 1096 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1M6P · Extracytoplasmic domain of bovine cation-dependent mannose 6-phosphate receptor · the same entry in another collection · chain A against A, TM-score 1.00
- P11456 · AlphaFold monomer V2.0 prediction for cation-dependent mannose-6-phosphate receptor… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11456
- Elsewhere: RCSB PDB 1M6P · PDBe 1M6P · UniProt P11456
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