GL1X · GenesisL1 explorer

MolNFT v1 · #143508 · protein + DNA

Hydrogen bonding complementary, not size complementarity is key in the formation of the double helix

6B1Q · Reverse transcriptase: “Hydrogen bonding complementary, not size complementarity is key in the formation of the double helix”. X-ray diffraction, 1 pocket (best druggability 0.47). MolNFT v1 #143508 on GenesisL1: 3D structure…

PDB
6B1Q
Type
protein + DNA
Length
258 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Reverse transcriptase; DNA (5'-D(*CP*TP*TP*AP*TP*(CJ1)P*(CJ1)P*(CJ1))-3'); DNA…
EC
2.7.7.49
UniProt
P03355
Pockets
1 · best druggability 0.47

Structure

x-ray diffraction · 3 distinct chains · 32% helix, 24% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AReverse transcriptase (EC 2.7.7.49)protein24232% helix, 24% strandP03355
BDNA (5'-D(*CP*TP*TP*AP*TP*(CJ1)P*(CJ1)P*(CJ1))-3')dna8——
GDNA (5'-D(P*(1AP)P*(1AP)P*(1AP)P*AP*TP*AP*AP*G)-3')dna8——

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1970.470.8021empty

Interfaces

3 interfaces between chains.

  • B–G · 343 Ų buried · 26 hydrogen bonds · nucleic-nucleic
  • A–B · 237 Ų buried · 4 hydrogen bonds · protein-nucleic
  • A–G · 194 Ų buried · 4 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 6 modified (nucleotide modification).

Compared structures

  • 6B1Q · Hydrogen Bonding Complementary, not size complementarity is key in the formation of the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.