MolNFT v1 · #143480 · protein
Crystal structure of the anti-circumsporozoite protein 1710 antibody
6B0W · 1710 antibody, light chain: “Crystal structure of the anti-circumsporozoite protein 1710 antibody”. X-ray diffraction, 5 pockets (best druggability 0.63). MolNFT v1 #143480 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6B0W
- Type
- protein
- Length
- 433 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1710 antibody, light chain; 1710 antibody, heavy chain
- Pockets
- 5 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | 1710 antibody, light chain | protein | 209 | 8% helix, 50% strand | — |
| H | 1710 antibody, heavy chain | protein | 224 | 10% helix, 51% strand | — |
Ligands and binding sites
- IPA · Isopropyl alcohol · additive · 6 copies · chains L, H
- GOL · Glycerol · additive · 6 copies · chains L, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 570 | 0.63 | 0.75 | 64 | empty |
| 2 | 79 | 0.45 | 0.81 | 20 | empty |
| 3 | 77 | 0.39 | 0.78 | 17 | empty |
| 4 | 59 | 0.31 | 0.76 | 18 | empty |
| 5 | 62 | 0.31 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- L–H · 1808 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6B0W · Crystal structure of the anti-circumsporozoite protein 1710 antibody · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6B0W · PDBe 6B0W
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