MolNFT v1 · #143451 · protein

Crystal structure of CFFPPS2 (apo form), a lepidopteran type-II farnesyl diphosphate synthase

6B02: “Crystal structure of CFFPPS2 (apo form), a lepidopteran type-II farnesyl diphosphate synthase”. X-ray diffraction, 9 pockets (best druggability 0.70). MolNFT v1 #143451 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6B02
Type: protein
Length: 665 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Farnesyl diphosphate synthase
EC: 2.5.1.-
UniProt: Q1XAB1
Pockets: 9 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 75% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Farnesyl diphosphate synthase (EC 2.5.1.-)	protein	336	73% helix, 1% strand	Q1XAB1
B	Farnesyl diphosphate synthase (EC 2.5.1.-)	protein	329	76% helix, 1% strand	Q1XAB1

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	540	0.70	0.79	51	empty
2	375	0.62	0.78	37	empty
3	260	0.56	0.78	32	empty
4	240	0.55	0.77	30	empty
5	68	0.38	0.79	17	empty

Interfaces

1 interface between chains.

A–B · 2038 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

6B02 · Crystal structure of CfFPPS2 (apo form), a lepidopteran type-II farnesyl diphosphate… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q1XAB1
Elsewhere: RCSB PDB 6B02 · PDBe 6B02 · UniProt Q1XAB1

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