MolNFT v1 · #143448 · protein

Crystal structure of HSP104 R328M/R757M mutant from calcarisporiella thermophila

6AZY · Heat shock protein HSP104: “Crystal structure of HSP104 R328M/R757M mutant from calcarisporiella thermophila”. X-ray diffraction, 1 ligand (ADP), 9 pockets (best druggability 0.72). MolNFT v1 #143448 on GenesisL1: 3D structure…

PDB: 6AZY
Type: protein
Length: 810 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock protein HSP104
Ligands: ADP
Pockets: 9 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 60% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock protein HSP104	protein	810	60% helix, 11% strand	—

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	825	0.72	0.77	76	empty
2	218	0.56	0.78	24	empty
3	131	0.53	0.81	21	empty
4	229	0.53	0.77	29	ADP
5	189	0.52	0.78	29	ADP

Compared structures

6AZY · Crystal structure of Hsp104 R328M/R757M mutant from Calcarisporiella thermophila · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6AZY · PDBe 6AZY

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