MolNFT v1 · #143399 · protein

Human apo-TRPML3 channel at pH 7.4

6AYE · Mucolipin-3: “Human apo-TRPML3 channel at pH 7.4”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #143399 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6AYE
Type: protein
Length: 1,904 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mucolipin-3
UniProt: Q8TDD5
Pockets: 20 · best druggability 0.87

Structure

electron microscopy · 1 distinct chain · 60% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Mucolipin-3	protein	476	60% helix, 14% strand	Q8TDD5

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	391	0.87	0.95	37	empty
2	170	0.73	0.91	24	empty
3	729	0.73	0.78	54	empty
4	793	0.73	0.78	62	empty
5	761	0.72	0.78	55	empty

Interfaces

6 interfaces between chains.

A–B · 3875 Å² buried · 38 hydrogen bonds · protein-protein
B–C · 3873 Å² buried · 38 hydrogen bonds · protein-protein
C–D · 3866 Å² buried · 38 hydrogen bonds · protein-protein
A–D · 3862 Å² buried · 37 hydrogen bonds · protein-protein
B–D · 36 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6AYE · Human apo-TRPML3 channel at pH 7.4 · the same entry in another collection · chain A against A, TM-score 1.00
Q8TDD5 · AlphaFold monomer V2.0 prediction for mucolipin-3 (Q8TDD5) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TDD5
Elsewhere: RCSB PDB 6AYE · PDBe 6AYE · UniProt Q8TDD5

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