MolNFT v1 · #143254 · protein

1.8 ångström crystal structure of the human BAG6-nls & TRC35 complex

6AU8 · Golgi to er traffic protein 4 homolog: “1.8 ångström crystal structure of the human BAG6-nls & TRC35 complex”. X-ray diffraction, 4 pockets (best druggability 0.49). MolNFT v1 #143254 on GenesisL1: 3D structure, binding sites and…

PDB: 6AU8
Type: protein
Length: 322 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Golgi to er traffic protein 4 homolog; Large proline-rich protein BAG6
UniProt: Q7L5D6, P46379
Pockets: 4 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Golgi to er traffic protein 4 homolog	protein	280	74% helix, 0% strand	Q7L5D6
C	Large proline-rich protein BAG6	protein	42	52% helix, 0% strand	P46379

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	213	0.49	0.75	39	GOL
2	146	0.47	0.77	21	empty
3	95	0.44	0.79	16	empty
4	75	0.37	0.77	13	empty

Interfaces

1 interface between chains.

A–C · 1360 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

6AU8 · 1.8 angstrom crystal structure of the human Bag6-NLS & TRC35 complex · the same entry in another collection · chain A against A, TM-score 1.00
Q7L5D6 · AlphaFold monomer V2.0 prediction for golgi to er traffic protein 4 homolog (Q7L5D6) · a predicted model of the same protein · chain A against A, TM-score 0.97
P46379 · AlphaFold monomer V2.0 prediction for large proline-rich protein BAG6 (P46379) · a predicted model of the same protein · chain C against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7L5D6
Every structure of UniProt P46379
Elsewhere: RCSB PDB 6AU8 · PDBe 6AU8 · UniProt Q7L5D6 · UniProt P46379

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