MolNFT v1 · #143241 · protein

The molecular mechanisms by which NS1 of the 1918 spanish influenza a virus hijack host protein-protein interactions

6ATV · Adapter molecule crk: “The molecular mechanisms by which NS1 of the 1918 spanish influenza a virus hijack host protein-protein…”. X-ray diffraction, 2 ligands (ACE, NH2). MolNFT v1 #143241 on GenesisL1: 3D structure, binding sites…

PDB: 6ATV
Type: protein
Length: 71 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adapter molecule crk; Proline-rich motif in iav-NS1
UniProt: P46108
Ligands: ACE, NH2

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adapter molecule crk	protein	58	5% helix, 47% strand	P46108
M	Proline-rich motif in iav-NS1	protein	13	0% helix, 0% strand	—

Ligands and binding sites

ACE · Acetyl group · ligand · chains M
NH2 · Amino group · ion · chains M

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–M · 593 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

6ATV · The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host… · the same entry in another collection · chain A against A, TM-score 1.00
P46108 · AlphaFold monomer V2.0 prediction for adapter molecule crk (P46108) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46108
Elsewhere: RCSB PDB 6ATV · PDBe 6ATV · UniProt P46108

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