MolNFT v1 · #143181 · protein
Structure of a phage anti-CRISPR protein
6AS3 · Nhis ACRE1 protein: “Structure of a phage anti-CRISPR protein”. X-ray diffraction, 4 pockets (best druggability 0.80). MolNFT v1 #143181 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6AS3
- Type
- protein
- Length
- 374 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nhis ACRE1 protein
- UniProt
- L7P7L6
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 80% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nhis ACRE1 protein | protein | 95 | 80% helix, 4% strand | L7P7L6 |
| B | Nhis ACRE1 protein | protein | 94 | 81% helix, 4% strand | L7P7L6 |
| C | Nhis ACRE1 protein | protein | 91 | 79% helix, 4% strand | L7P7L6 |
| D | Nhis ACRE1 protein | protein | 94 | 80% helix, 4% strand | L7P7L6 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1009 | 0.80 | 0.81 | 59 | empty |
| 2 | 66 | 0.57 | 0.88 | 25 | empty |
| 3 | 92 | 0.44 | 0.79 | 16 | empty |
| 4 | 76 | 0.43 | 0.81 | 14 | empty |
Interfaces
6 interfaces between chains.
- B–D · 2012 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 1973 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 544 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 146 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 38 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6AS3 · Structure of a phage anti-CRISPR protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt L7P7L6
- Elsewhere: RCSB PDB 6AS3 · PDBe 6AS3 · UniProt L7P7L6
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