MolNFT v1 · #143100 · protein

Crystal structure of infant antibody adi-19425

6APC · Epididymis luminal protein 214: “Crystal structure of infant antibody adi-19425”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.75). MolNFT v1 #143100 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6APC
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Epididymis luminal protein 214; Igl@ protein
UniProt: Q6GMX4
Ligands: SO4
Pockets: 5 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Epididymis luminal protein 214	protein	223	7% helix, 51% strand	—
L	Igl@ protein	protein	213	9% helix, 51% strand	Q6GMX4

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains H, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1022	0.75	0.77	80	SO4
2	90	0.37	0.76	17	empty
3	77	0.37	0.77	20	empty
4	89	0.37	0.75	20	empty
5	51	0.27	0.74	18	empty

Interfaces

1 interface between chains.

H–L · 1880 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6APC · Crystal Structure of Infant Antibody ADI-19425 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6GMX4
Elsewhere: RCSB PDB 6APC · PDBe 6APC · UniProt Q6GMX4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.