MolNFT v1 · #143021 · protein

ABL1B regulatory module 'activating' conformation

6AMW · Tyrosine-protein kinase ABL1: “ABL1B regulatory module 'activating' conformation”. Solution nmr, 4 pockets (best druggability 0.79). MolNFT v1 #143021 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6AMW
Type: protein
Length: 255 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein kinase ABL1
EC: 2.7.10.2
UniProt: P00519
Pockets: 4 · best druggability 0.79

Structure

solution nmr · 1 distinct chain · 9% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase ABL1 (EC 2.7.10.2)	protein	255	9% helix, 24% strand	P00519

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	895	0.79	0.81	72	empty
2	177	0.62	0.84	28	empty
3	83	0.49	0.83	20	empty
4	83	0.48	0.83	19	empty

Compared structures

6AMW · Abl1b Regulatory Module 'Activating' conformation · the same entry in another collection · chain A against A, TM-score 1.00
P00519 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase ABL1 (P00519) · a predicted model of the same protein · chain A against A, TM-score 0.44

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00519
Elsewhere: RCSB PDB 6AMW · PDBe 6AMW · UniProt P00519

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