Crystal structure of bone morphogenetic protein-7 (bmp-7) in complex with the secreted antagonist noggin

Structure

x-ray diffraction · 2 distinct chains · 21% helix, 32% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• L–A · 390 Ų buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 1M4U · Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted… · the same entry in another collection · chain L against L, TM-score 1.00
• Q13253 · AlphaFold monomer V2.0 prediction for noggin (Q13253) · a predicted model of the same protein · chain A against A, TM-score 0.96
• P18075 · AlphaFold monomer V2.0 prediction for bone morphogenetic protein 7 (P18075) · a predicted model of the same protein · chain L against A, TM-score 0.80

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P18075
• Every structure of UniProt Q13253
• Elsewhere: RCSB PDB 1M4U · PDBe 1M4U · UniProt P18075 · UniProt Q13253