MolNFT v1 · #142943 · protein
Crystal structure of STRIATIN3 in complex with SIKE1 coiled-coil domain
6AKL · Suppressor of ikbke 1: “Crystal structure of STRIATIN3 in complex with SIKE1 coiled-coil domain”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #142943 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6AKL
- Type
- protein
- Length
- 118 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Suppressor of ikbke 1; Striatin-3
- UniProt
- Q9BRV8, Q13033
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 3 distinct chains · 86% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppressor of ikbke 1 | protein | 52 | 90% helix, 0% strand | Q9BRV8 |
| B | Suppressor of ikbke 1 | protein | 47 | 94% helix, 0% strand | Q9BRV8 |
| C | Striatin-3 | protein | 19 | 58% helix, 0% strand | Q13033 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 84 | 0.37 | 0.76 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1257 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 398 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 290 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6AKL · Crystal structure of Striatin3 in complex with SIKE1 Coiled-coil domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BRV8 · AlphaFold monomer V2.0 prediction for suppressor of ikbke 1 (Q9BRV8) · a predicted model of the same protein · chain B against A, TM-score 0.94
- Q13033 · AlphaFold monomer V2.0 prediction for striatin-3 (Q13033) · a predicted model of the same protein · chain C against A, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BRV8
- Every structure of UniProt Q13033
- Elsewhere: RCSB PDB 6AKL · PDBe 6AKL · UniProt Q9BRV8 · UniProt Q13033
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