MolNFT v1 · #142942 · protein

Crystal structure of the second coiled-coil domain of SIKE1

6AKK · Suppressor of ikbke 1: “Crystal structure of the second coiled-coil domain of SIKE1”. X-ray diffraction, 2 pockets (best druggability 0.31). MolNFT v1 #142942 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6AKK
Type: protein
Length: 97 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Suppressor of ikbke 1
UniProt: Q9BRV8
Pockets: 2 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 90% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Suppressor of ikbke 1	protein	49	90% helix, 0% strand	Q9BRV8
B	Suppressor of ikbke 1	protein	48	90% helix, 0% strand	Q9BRV8

Ligands and binding sites

GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.31	0.74	16	empty
2	51	0.28	0.74	13	empty

Interfaces

1 interface between chains.

A–B · 487 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6AKK · Crystal structure of the second Coiled-coil domain of SIKE1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9BRV8 · AlphaFold monomer V2.0 prediction for suppressor of ikbke 1 (Q9BRV8) · a predicted model of the same protein · chain B against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BRV8
Elsewhere: RCSB PDB 6AKK · PDBe 6AKK · UniProt Q9BRV8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.