MolNFT v1 · #142941 · protein

The crystal structure of emc complex

6AKJ · Enhancer of rudimentary HOMOLOG,YTH domain-containing…: “The crystal structure of emc complex”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.30). MolNFT v1 #142941 on GenesisL1: 3D structure, binding sites and…

PDB: 6AKJ
Type: protein
Length: 216 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Enhancer of rudimentary HOMOLOG,YTH domain-containing protein MMI1 fusion protein
UniProt: K7PD52, O74958
Ligands: SO4
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Enhancer of rudimentary HOMOLOG,YTH domain-containing protein MMI1 fusion protein	protein	106	40% helix, 24% strand	K7PD52, O74958
B	Enhancer of rudimentary HOMOLOG,YTH domain-containing protein MMI1 fusion protein	protein	110	42% helix, 23% strand	K7PD52, O74958

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.30	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 1392 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

6AKJ · The crystal structure of EMC complex · the same entry in another collection · chain A against A, TM-score 1.00
O74958 · AlphaFold monomer V2.0 prediction for RNA binding exosome specificity factor MMI1 (O74958) · a predicted model of the same protein · chain A against A, TM-score 0.35

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt K7PD52
Every structure of UniProt O74958
Elsewhere: RCSB PDB 6AKJ · PDBe 6AKJ · UniProt K7PD52 · UniProt O74958

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