MolNFT v1 · #14291 · protein
Structure of the TSG101 uev domain in complex with a HIV-1 ptap "late domain" peptide, dyana ensemble
1M4P · Tumor susceptibility gene 101 protein: “Structure of the TSG101 uev domain in complex with a HIV-1 ptap "late domain" peptide, dyana ensemble”. Solution nmr, 2 pockets (best druggability 0.57). MolNFT v1 #14291 on GenesisL1: 3D…
- PDB
- 1M4P
- Type
- protein
- Length
- 153 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor susceptibility gene 101 protein; Gag polyprotein
- UniProt
- Q99816, Q9IF21
- Pockets
- 2 · best druggability 0.57
Structure
solution nmr · 2 distinct chains · 24% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tumor susceptibility gene 101 protein | protein | 144 | 26% helix, 25% strand | Q99816 |
| B | Gag polyprotein | protein | 9 | 0% helix, 11% strand | Q9IF21 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.57 | 0.84 | 23 | empty |
| 2 | 128 | 0.55 | 0.82 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 539 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1M4P · Structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP late domain" peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q99816 · AlphaFold monomer V2.0 prediction for tumor susceptibility gene 101 protein (Q99816) · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99816
- Every structure of UniProt Q9IF21
- Elsewhere: RCSB PDB 1M4P · PDBe 1M4P · UniProt Q99816 · UniProt Q9IF21
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