MolNFT v1 · #142874 · protein

Crystal structure of a new form of rsmd-like RNA methyl transferase from mycobacterium tuberculosis determined at 1.74 a resolution

6AIE · Putative methyltransferase: “Crystal structure of a new form of rsmd-like RNA methyl transferase from mycobacterium tuberculosis…”. X-ray diffraction, 4 pockets (best druggability 0.69). MolNFT v1 #142874 on GenesisL1: 3D structure…

PDB: 6AIE
Type: protein
Length: 546 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative methyltransferase
EC: 2.1.1.171
UniProt: A0A045IDU3
Pockets: 4 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Putative methyltransferase (EC 2.1.1.171)	protein	182	31% helix, 26% strand	A0A045IDU3

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	605	0.69	0.78	62	empty
2	297	0.64	0.81	32	empty
3	270	0.59	0.79	33	empty
4	323	0.57	0.76	32	empty

Interfaces

2 interfaces between chains.

A–B · 518 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 238 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6AIE · Crystal structure of a new form of RsmD-like RNA methyl transferase from Mycobacterium… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A045IDU3
Elsewhere: RCSB PDB 6AIE · PDBe 6AIE · UniProt A0A045IDU3

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