MolNFT v1 · #142857 · protein
Crystal structure of circular-permutated yibk methyltransferase from haemophilus influenzae
6AHW · Circular-permutated tRNA (CYTIDINE(34)-2'-O)…: “Crystal structure of circular-permutated yibk methyltransferase from haemophilus influenzae”. X-ray diffraction, 6 pockets (best druggability 0.61). MolNFT v1 #142857 on GenesisL1: 3D…
- PDB
- 6AHW
- Type
- protein
- Length
- 324 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Circular-permutated tRNA (CYTIDINE(34)-2'-O)- methyltransferase
- EC
- 2.1.1.207
- UniProt
- P44868
- Pockets
- 6 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Circular-permutated tRNA (CYTIDINE(34)-2'-O)- methyltransferase (EC 2.1.1.207) | protein | 162 | 33% helix, 15% strand | P44868 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.61 | 0.83 | 40 | empty |
| 2 | 202 | 0.61 | 0.82 | 38 | empty |
| 3 | 156 | 0.49 | 0.78 | 30 | empty |
| 4 | 199 | 0.49 | 0.76 | 35 | empty |
| 5 | 114 | 0.41 | 0.76 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1515 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 6AHW · Crystal structure of circular-permutated YibK methyltransferase from Haemophilus… · the same entry in another collection · chain A against A, TM-score 1.00
- P44868 · AlphaFold monomer V2.0 prediction for tRNA (CYTIDINE(34)-2'-O)-methyltransferase (P44868) · a predicted model of the same protein · chain A against A, TM-score 0.46
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P44868
- Elsewhere: RCSB PDB 6AHW · PDBe 6AHW · UniProt P44868
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