MolNFT v1 · #142856 · protein

Crystal structure of human RPP40

6AHV · Ribonuclease P protein subunit P40: “Crystal structure of human RPP40”. X-ray diffraction, 3 pockets (best druggability 0.67). MolNFT v1 #142856 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6AHV
Type: protein
Length: 345 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease P protein subunit P40
EC: 3.1.26.5
UniProt: O75818
Pockets: 3 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribonuclease P protein subunit P40 (EC 3.1.26.5)	protein	345	26% helix, 39% strand	O75818

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	313	0.67	0.82	53	empty
2	89	0.35	0.74	22	empty
3	59	0.26	0.72	12	empty

Compared structures

6AHV · Crystal structure of human RPP40 · the same entry in another collection · chain A against A, TM-score 1.00
O75818 · AlphaFold monomer V2.0 prediction for ribonuclease P protein subunit P40 (O75818) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75818
Elsewhere: RCSB PDB 6AHV · PDBe 6AHV · UniProt O75818

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