MolNFT v1 · #142838 · protein

M500V mutant of coronin coiled coil domain

6AH6 · Coronin-like protein: “M500V mutant of coronin coiled coil domain”. X-ray diffraction, 3 pockets (best druggability 0.71). MolNFT v1 #142838 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6AH6
Type: protein
Length: 192 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Coronin-like protein
UniProt: Q3T1U8
Pockets: 3 · best druggability 0.71

Structure

x-ray diffraction · 4 distinct chains · 94% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Coronin-like protein	protein	49	94% helix, 0% strand	Q3T1U8
B	Coronin-like protein	protein	47	91% helix, 0% strand	Q3T1U8
C	Coronin-like protein	protein	46	96% helix, 0% strand	Q3T1U8
D	Coronin-like protein	protein	50	94% helix, 0% strand	Q3T1U8

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.71	0.99	13	empty
2	120	0.45	0.77	20	empty
3	85	0.36	0.75	23	empty

Interfaces

6 interfaces between chains.

A–B · 909 Å² buried · 3 hydrogen bonds · protein-protein
C–D · 855 Å² buried · 1 hydrogen bond · protein-protein
A–D · 774 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 706 Å² buried · 10 hydrogen bonds · protein-protein
B–D · 208 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6AH6 · M500V mutant of Coronin coiled coil domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3T1U8
Elsewhere: RCSB PDB 6AH6 · PDBe 6AH6 · UniProt Q3T1U8

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