MolNFT v1 · #142759 · protein
Cryo-EM structure of the receptor-activated TRPC5 ion channel
6AEI · Short transient receptor potential channel 5: “Cryo-EM structure of the receptor-activated TRPC5 ion channel”. Electron microscopy, 3 ligands (Y01, LPP, NA), 20 pockets (best druggability 0.84). MolNFT v1 #142759 on GenesisL1: 3D…
- PDB
- 6AEI
- Type
- protein
- Length
- 2,568 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Short transient receptor potential channel 5
- UniProt
- Q9QX29
- Ligands
- Y01, LPP, NA
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 65% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Short transient receptor potential channel 5 | protein | 642 | 65% helix, 1% strand | Q9QX29 |
Ligands and binding sites
- Y01 · Cholesterol hemisuccinate · ligand · 4 copies · chains A, D, B, C
- LPP · 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate · ligand · 4 copies · chains A, D, B, C
- NA · Sodium ion · metal · 5 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1041 | 0.84 | 0.85 | 79 | NA |
| 2 | 1041 | 0.82 | 0.83 | 77 | NA |
| 3 | 836 | 0.82 | 0.85 | 86 | empty |
| 4 | 1064 | 0.82 | 0.82 | 80 | NA |
| 5 | 1024 | 0.82 | 0.83 | 95 | empty |
Interfaces
6 interfaces between chains.
- A–D · 4386 Ų buried · 29 hydrogen bonds · protein-protein
- A–B · 4306 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 4279 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 4211 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 85 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6AEI · Cryo-EM structure of the receptor-activated TRPC5 ion channel · the same entry in another collection · chain A against A, TM-score 1.00
- Q9QX29 · AlphaFold monomer V2.0 prediction for short transient receptor potential channel 5… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9QX29
- Elsewhere: RCSB PDB 6AEI · PDBe 6AEI · UniProt Q9QX29
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.