MolNFT v1 · #142755 · protein
Crystal structure of the four ig-like domains of LILRB1 complexed with HLA-G
6AEE · HLA class I histocompatibility antigen, alpha chain G: “Crystal structure of the four ig-like domains of LILRB1 complexed with HLA-G”. X-ray diffraction, 20 pockets (best druggability 0.78). MolNFT v1 #142755 on GenesisL1: 3D…
- PDB
- 6AEE
- Type
- protein
- Length
- 1,499 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, alpha chain G; Beta-2-microglobulin; 9 mer…
- UniProt
- P17693, P61769, A0A0G2JQ44
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 5 distinct chains · 9% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | HLA class I histocompatibility antigen, alpha chain G | protein | 275 | 27% helix, 40% strand | P17693 |
| B, E | Beta-2-microglobulin | protein | 100 | 0% helix, 53% strand | P61769 |
| C, F | 9 mer peptide (RL9) from histone H2A.X | protein | 9 | 0% helix, 0% strand | — |
| G | Leukocyte immunoglobulin-like receptor subfamily B member 1 | protein | 369 | 2% helix, 43% strand | A0A0G2JQ44 |
| H | Leukocyte immunoglobulin-like receptor subfamily B member 1 | protein | 362 | 4% helix, 41% strand | A0A0G2JQ44 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 713 | 0.78 | 0.83 | 59 | empty |
| 2 | 808 | 0.76 | 0.80 | 74 | empty |
| 3 | 451 | 0.70 | 0.81 | 52 | empty |
| 4 | 456 | 0.69 | 0.81 | 42 | empty |
| 5 | 684 | 0.68 | 0.76 | 61 | empty |
Interfaces
11 interfaces between chains.
- D–E · 1359 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 1344 Ų buried · 20 hydrogen bonds · protein-protein
- D–F · 1008 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 1001 Ų buried · 22 hydrogen bonds · protein-protein
- B–G · 624 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 6AEE · Crystal structure of the four Ig-like domains of LILRB1 complexed with HLA-G · the same entry in another collection · chain H against H, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P17693 · AlphaFold monomer V2.0 prediction for HLA class I histocompatibility antigen, alpha chain… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17693
- Every structure of UniProt P61769
- Every structure of UniProt A0A0G2JQ44
- Elsewhere: RCSB PDB 6AEE · PDBe 6AEE · UniProt P17693 · UniProt P61769 · UniProt A0A0G2JQ44
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