MolNFT v1 · #142743 · protein
Crystal structure of CSM3 of the type III-a CRISPR-CAS effector complex
6AE2: “Crystal structure of CSM3 of the type III-a CRISPR-CAS effector complex”. X-ray diffraction, 3 pockets (best druggability 0.60). MolNFT v1 #142743 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6AE2
- Type
- protein
- Length
- 361 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CSM3
- UniProt
- Q97CJ2
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CSM3 | protein | 181 | 24% helix, 36% strand | Q97CJ2 |
| B | CSM3 | protein | 180 | 29% helix, 37% strand | Q97CJ2 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 320 | 0.60 | 0.78 | 41 | empty |
| 2 | 92 | 0.58 | 0.86 | 17 | empty |
| 3 | 63 | 0.27 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1063 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6AE2 · Crystal structure of Csm3 of the type III-A CRISPR-Cas effector complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q97CJ2
- Elsewhere: RCSB PDB 6AE2 · PDBe 6AE2 · UniProt Q97CJ2
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